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Alternatively, the MycG4 is a promising anticancer drug target because of its function as transcription silencer and is one of the most studied G4s for small molecule targeting. The MYC protein is an important transcription factor that is commonly deregulated in human cancers however, it is often considered ‘undruggable’. A prominent example and model structure for parallel G4s with short loops is the major G4 formed in the promoter region of the MYC oncogene, MycG4 ( Figure 1a). Parallel G4s are prevalent in the human genome, such as promoter DNA G4s and RNA G4s. In parallel G4s, the 5′- and 3′-terminal flanking regions mostly form capping structures over the external G-tetrads, whereas in non-parallel G4s, the loop regions are also involved in capping structure formation. G4s can be classed as parallel and non-parallel structures depending on the directionality of the involved G-runs, which are connected by loop sequences. 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The G4 formed in the MYC promoter (MycG4) is one of the most studied small-molecule targets, and a model system for parallel structures that are prevalent in promoter DNA G4s and RNA G4s. G-quadruplexes are four-stranded nucleic acid secondary structures of biological significance and have emerged as an attractive drug target. ![]() ![]() ![]() For example, with DoorDash you can deliver using your car, bike or scooter.Īnnual Salary Range: $16,918 – $46,324 2. And the best part is, you might not even need a car. Starting with a company as a driver can also help you get your foot in the door, with opportunities to work towards a higher-paying position.Ĭompanies like DoorDash, Uber Eats, and Instacart may have availability for new delivery-partners in your area. You don’t need any experience for many of these jobs, and they often offer a lot of scheduling flexibility. As long as you have a clean driver’s license, you are eligible for these jobs. 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